Preheat oven to 425° and cut chicken breasts into about 1 inch cubes.
For the breading, you will need three separate bowls: 1 for the egg mixture, 1 for the flour mixture, and 1 for the Panko breadcrumbs. Combine flour, paprika, garlic powder, salt, pepper and cayenne in medium sized bowl. In your second bowl, crack 3 eggs and beat until combined. In the third bowl add the Panko breadcrumbs.
For this step it's easiest to make an assembly line with the chicken, flour mixture, egg mixture then breadcrumbs. Take the cubed chicken pieces and roll in the flour mixture making sure to completely cover all sides. Next add the floured chicken into the egg mixture. Finally, take that chicken and dredge in the Panko breadcrumbs. Make sure the entire chicken piece is coated in every step, and then place on jelly roll pan lined with parchment paper. Repeat until all pieces of chicken are done! Space on the pan so they aren't touching.
Cook the chicken pieces in the 425° oven on the middle rack for 15 minutes. When the time is up, leave the chicken in the oven and set the heat to 500° for an additional 5-8 minutes, or until golden brown. This will ensure the chicken is crispy!